Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 1.00 |
| ▸ | HSD17B2 | P37059 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.59 |
| ▸ | TOP1 | P11387 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | SNCA | P37840 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12199347 | 0.86 | HSD17B1 (0.76) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12199323 | 0.86 | HSD17B1 (0.76) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31024 | 0.86 | HSD17B1 (0.82) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30399 | 0.85 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29710 | 0.84 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12199320 | 0.83 | HSD17B1 (0.81) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13329184 | 0.83 | HSD17B1 (0.81) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16554035 | 0.82 | HSD17B1 (0.76) | HSD17B1HSD17B2LRRK2SCDDYRK1A | |
| SCHEMBL31035 | 0.82 | HSD17B1 (1.00) | HSD17B1HSD17B2LRRK2SCDDYRK1A | |
| SCHEMBL29964 | 0.82 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |