Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124260 | 1.00 | ACHE (0.47) | ACHERECQLNPC1RAB9APDE4A | |
| SCHEMBL16440160 | 0.83 | ACHE (0.59) | ACHERECQLNPC1RAB9APDE4A | |
| SCHEMBL2907378 | 0.83 | ACHE (0.59) | ACHERECQLNPC1RAB9APDE4A | |
| SCHEMBL3121648 | 0.82 | CYP11B2 (0.45) | RECQLPDE4APDE5APDE1APDE1B | |
| SCHEMBL3121642 | 0.82 | CYP11B2 (0.45) | RECQLPDE4APDE5APDE1APDE1B | |
| SCHEMBL10196687 | 0.82 | ACHE (0.57) | ACHERECQLNPC1RAB9APDE4A | |
| SCHEMBL15280209 | 0.80 | ACHE (0.63) | ACHERECQLNPC1RAB9APDE4A | |
| SCHEMBL6873641 | 0.77 | PDE4A (0.60) | ACHEPDE4APDE5APDE1APDE1B | |
| SCHEMBL3120758 | 0.75 | EGFR (0.40) | ALDH1A1MEN1MAPTALOX12KMT2A | |
| SCHEMBL10196388 | 0.74 | PDE4D (0.53) | ACHEPDE4ASYKPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |