Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | PDE1A | P54750 | 2/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | VEGFA | P15692 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907378 | 0.93 | ACHE (0.59) | PDE4AACHEPDE4BPDE4DPDE4C | |
| SCHEMBL10196687 | 0.91 | ACHE (0.57) | PDE4AACHEPDE4BPDE4DPDE4C | |
| SCHEMBL16440160 | 0.89 | ACHE (0.59) | PDE4AACHEPDE4BPDE4DPDE4C | |
| SCHEMBL15280209 | 0.85 | ACHE (0.63) | PDE4AACHEPDE4BPDE4DPDE4C | |
| SCHEMBL12409078 | 0.85 | PDE4B (0.56) | PDE4AACHEPDE4BPDE4DPDE4C | |
| SCHEMBL5823060 | 0.84 | PDE4A (0.77) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL1157478 | 0.83 | POLB (0.59) | PDE4APDE4BPDE4DPDE4CPDE5A | |
| SCHEMBL27521810 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4CPDE5A | |
| SCHEMBL12908030 | 0.82 | CSNK2A1 (0.59) | PDE4APDE4BPDE4DPDE4CPDE5A | |
| SCHEMBL12794525 | 0.81 | ADRB2 (0.48) | PDE4AACHEPDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1537018-A | Therapeutic compositions for repairing chondropathy | 田边制药株式会社 | 2004-10-13 | — | — | CN | claimed |
| CN-1520313-A | Compsns. for promoting healing of bone racture | ������ҩ��ʽ���� | 2004-08-11 | — | — | CN | claimed |
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10562897-B2 | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-18 | — | — | US | disclosed |
| US-10246454-B2 | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-04-02 | — | — | US | disclosed |
| US-20190000860-A1 | USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| US-20170145023-A1 | DIAZEPANE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-20170145013-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| EP-2604260-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SHIONOGI & CO (JP) | 2017-05-10 | — | — | EP | disclosed |
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2016201370-A1 | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
| US-20070259874-A1 | Phosphodiesterase Inhibitors | RANBAXY LABORATORIES LIMITED (IN) | 2007-11-08 | — | — | US | disclosed |
| US-20070259874-A1 | Phosphodiesterase Inhibitors | RANBAXY LABORATORIES LIMITED (IN) | 2007-11-08 | — | — | US | disclosed |
| WO-2007107352-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2007-09-27 | — | — | WO | disclosed |
| US-20070179167-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
| US-20070167440-A1 | Novel pyrrolidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-07-19 | — | — | US | disclosed |
| US-20070167440-A1 | Novel pyrrolidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-07-19 | — | — | US | disclosed |
| WO-2007025307-A2 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2005051931-A2 | PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2005-06-09 | — | — | WO | disclosed |
| CN-1350453-A | Method for treating exercise induced asthma | SMITHKLINE BEECHAM CORP (US) | 2002-05-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190000860-A1 | USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD) | BCL6, BCL6B, EZH2 | PDE4A 3748/4885ACHE 4661/4885PDE4B 3710/4885 |
| US-10246454-B2 | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators | BACE1, BACE2, PSEN1 | PDE4A 495/4885ACHE 19/4885PDE4B 667/4885 |
| US-20070167440-A1 | Novel pyrrolidine compound and a process for preparing the same | CNR1, CNR2, OPRD1 | PDE4A 2781/4885ACHE 2230/4885PDE4B 2011/4885 |
| US-20070179167-A1 | Inhibitors of serine proteases | PRSS1, PRSS3, PRSS2 | PDE4A 1445/4885ACHE 2639/4885PDE4B 2357/4885 |
| US-20070259874-A1 | Phosphodiesterase Inhibitors | PDE4A, PDE3B, PDE7A | PDE4A 1/4885ACHE 235/4885PDE4B 4/4885 |
| US-20170145013-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BRD3 | PDE4A 2071/4885ACHE 4247/4885PDE4B 2243/4885 |
| US-10562897-B2 | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators | BACE1, BACE2, PSEN1 | PDE4A 495/4885ACHE 19/4885PDE4B 667/4885 |
| US-20170145023-A1 | DIAZEPANE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BAZ2A | PDE4A 1773/4885ACHE 3258/4885PDE4B 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.