SCHEMBL31159930

SCHEMBL31159930

COC(=O)c1cc(NC[C@@H]2CCO2)c(NC(=O)C(C)Cl)c(OC)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.37
▸ KDM4E B2RXH2 4/20 0.37
▸ ALDH1A1 P00352 6/20 0.37
▸ HPGD P15428 3/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ HSD17B10 Q99714 2/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ GAA P10253 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ XBP1 P17861 1/20 0.35
▸ ROCK2 O75116 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25383676 0.82 ALDH1A1 (0.44) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL25385087 0.82 ALDH1A1 (0.44) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL25383674 0.82 ALDH1A1 (0.44) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL25383670 0.82 ALDH1A1 (0.44) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL27176929 0.79 KDM4E (0.42) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL31160040 0.78 POLB (0.40) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL31159766 0.78 ALDH1A1 (0.40) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL30966733 0.76 HPGD (0.36) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL27255582 0.76 HPGD (0.36) KMT2AKDM4EALDH1A1HPGDMEN1
SCHEMBL29170113 0.75 MAPT (0.46) KMT2AKDM4EALDH1A1HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688144-A1 COMPOUNDS AS GLP-1R AGONISTS Terns Pharmaceuticals, Inc. (US) 2026-02-11 — — EP disclosed
WO-2024206878-A1 COMPOUNDS AS GLP-1R AGONISTS TERNS PHARMACEUTICALS, INC. (US) 2024-10-03 — — WO disclosed
Send feedback