SCHEMBL311636

SCHEMBL311636

Oc1ccc(-n2cnnn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 1.00
NOTUM Q6P988 5/20 0.64
F2 P00734 1/20 0.64
ALDH1A1 P00352 3/20 0.61
KCNJ1 P48048 3/20 0.61
LMNA P02545 1/20 0.58
HTT P42858 1/20 0.58
HPGD P15428 1/20 0.51
POLB P06746 1/20 0.51
BLM P54132 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
RAB9A P51151 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12615985 0.89 NOTUM (0.78) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL11711879 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL17993966 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL10738426 0.78 NOTUM (1.00) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL11118984 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL82595 0.78 MAPT (0.69) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL11831417 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL4582384 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL1163779 0.78 NOTUM (0.64) MAPTNOTUMF2ALDH1A1KCNJ1
SCHEMBL8485436 0.78 KCNJ1 (0.66) MAPTNOTUMF2ALDH1A1KCNJ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103657338-B Process for absorbing acid compounds contained in gaseous effluents using an aqueous solution based on amines IFP新能源公司 2017-08-25 CN claimed
JP-8134201-A None JP disclosed
JP-8208826-A None JP disclosed
US-20240358710-A1 METHODS, COMPOSITIONS AND DEVICES FOR TREATING CANCER WITH ILLUDOFULVENES AF CHEMICALS, LLC (US) 2024-10-31 US disclosed
US-12023339-B2 Methods, compositions and devices for treating cancer with illudofulvenes AF CHEMICALS, LLC (US) 2024-07-02 US disclosed
US-11591295-B2 Affinity illudofulvene conjugates AF CHEMICALS LLC (US) 2023-02-28 US disclosed
EP-3440078-B1 HETEROCYCLIC GPR119 AGONIST COMPOUNDS MANKIND PHARMA LTD (IN) 2022-09-28 EP disclosed
CN-109415359-B Heterocyclic GPR119 agonist compounds 人类制药有限公司 2022-03-04 CN disclosed
US-20220040191-A1 METHODS, COMPOSITIONS AND DEVICES FOR TREATING CANCER WITH ILLUDOFULVENES AF CHEMICALS, LLC (US) 2022-02-10 US disclosed
EP-3342765-B1 CATHEPSIN K INHIBITOR AND APPLICATION THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2021-09-15 EP disclosed
US-5843966-A Piperidine derivatives GLAXO GROUP LIMITED (GB) 1998-12-01 US disclosed
EP-0720609-B1 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS GLAXO GROUP LTD (GB) 1998-11-11 EP disclosed
US-5703240-A ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS GLAXO GROUP LIMITED (GB) 1997-12-30 US disclosed
EP-0802912-A1 PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY GLAXO GROUP LIMITED (GB) 1997-10-29 EP disclosed
CN-1162596-A Antiarrhythmic Agents AMERICAN CYANAMID CO (US) 1997-10-22 CN disclosed
JP-H08208826-A PRODUCTION OF POLYCARBONATE IDEMITSU KOSAN CO LTD 1996-08-13 JP disclosed
WO-1996021661-A1 PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY GLAXO GROUP LIMITED (GB) 1996-07-18 WO disclosed
EP-0720609-A1 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS GLAXO GROUP LIMITED (GB) 1996-07-10 EP disclosed
JP-H08134201-A POLYCARBONATE RESIN IDEMITSU KOSAN CO LTD 1996-05-28 JP disclosed
WO-1995008549-A1 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS GLAXO GROUP LIMITED (GB) 1995-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220040191-A1 METHODS, COMPOSITIONS AND DEVICES FOR TREATING CANCER WITH ILLUDOFULVENES MYC, MYCBP, TP53 MAPT 3248/4885NOTUM 4632/4885F2 1600/4885
US-20240358710-A1 METHODS, COMPOSITIONS AND DEVICES FOR TREATING CANCER WITH ILLUDOFULVENES MYC, MYCBP, TP53 MAPT 3248/4885NOTUM 4632/4885F2 1600/4885
US-11591295-B2 Affinity illudofulvene conjugates OGFR, TNFSF11, FCER2 MAPT 2405/4885NOTUM 2739/4885F2 745/4885
US-12023339-B2 Methods, compositions and devices for treating cancer with illudofulvenes MYC, MYCBP, TP53 MAPT 3248/4885NOTUM 4632/4885F2 1600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.