Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.43 |
| ▸ | AKT1 | P31749 | 7/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312365 | 0.85 | GPR119 (0.45) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL311144 | 0.83 | RPS6KB1 (0.47) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL30228278 | 0.76 | TRPV1 (0.46) | TRPC3TRPC7ALDH1A1USP2LMNA | |
| SCHEMBL311017 | 0.74 | GPR119 (0.46) | RPS6KB1AKT1HTT | |
| Hydrochloric Acid SCHEMBL310743 | 0.73 | MEN1 (0.57) | TLR8RPS6KB1AKT1CASP6 | |
| SCHEMBL15732488 | 0.73 | P2RY14 (0.51) | RPS6KB1ALDH1A1USP2MAPK1HTT | |
| SCHEMBL786550 | 0.73 | RPS6KB1 (0.43) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL13420671 | 0.72 | CHRM3 (0.49) | P2RY12ALDH1A1 | |
| SCHEMBL30177305 | 0.72 | MGLL (0.51) | DRD2ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL8821912 | 0.71 | SIGMAR1 (0.49) | RPS6KB1AKT1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093383-B2 | P70 S6 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | TLR8 4200/4885RPS6KB1 6/4885AKT1 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.