Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311791 | 0.91 | HPGD (0.51) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL312223 | 0.91 | AKR1B1 (0.56) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL324201 | 0.87 | HPGD (0.61) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL311620 | 0.86 | AKR1B1 (0.43) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL312670 | 0.86 | HPGD (0.42) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL312609 | 0.84 | HPGD (0.42) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL312050 | 0.84 | KDM4E (0.44) | HPGDKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL312477 | 0.84 | BACE1 (0.61) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL313004 | 0.84 | ATM (0.52) | HPGDKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL311364 | 0.84 | HPGD (0.44) | AKR1B1HPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |