Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311431 | 0.89 | HPGD (0.46) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL311741 | 0.87 | KDM4E (0.40) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL311791 | 0.86 | HPGD (0.51) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL311784 | 0.84 | AKR1B1 (0.46) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL313540 | 0.84 | MAPT (0.41) | HPGDKDM4ESMN1; SMN2CYP2C19CYP2C9 | |
| SCHEMBL312223 | 0.84 | AKR1B1 (0.56) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL312477 | 0.83 | BACE1 (0.61) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL312020 | 0.83 | HPGD (0.40) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL324201 | 0.82 | HPGD (0.61) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL311904 | 0.82 | HPGD (0.40) | HPGDKDM4EHSD17B10LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |