Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.65 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.65 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.65 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818989 | 1.00 | S1PR2 (0.65) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL8818981 | 1.00 | S1PR2 (0.65) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL3118704 | 1.00 | S1PR2 (0.65) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL21984539 | 0.98 | S1PR2 (0.61) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL5362759 | 0.95 | S1PR2 (0.63) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL10974751 | 0.93 | S1PR2 (0.55) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL8820729 | 0.91 | S1PR2 (0.65) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL31570922 | 0.91 | S1PR2 (0.65) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL9407912 | 0.88 | S1PR2 (0.67) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL14823590 | 0.88 | S1PR2 (0.52) | S1PR2S1PR4S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9295937-A | — | — | None | — | — | JP | disclosed |
| US-8946302-B2 | Selective sigma-1 receptor ligands | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20130102571-A1 | SELECTIVE SIGMA-1 RECEPTOR LIGANDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-25 | — | — | US | disclosed |
| US-8349898-B2 | Sigma-1 receptor ligands and methods of use | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-01-08 | — | — | US | disclosed |
| US-20100179111-A1 | SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE | WARF - WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-15 | — | — | US | disclosed |
| JP-H09295937-A | SIGMA RECEPTOR BONDING INHIBITOR | SUMITOMO PHARMACEUT CO LTD | 1997-11-18 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179111-A1 | SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE | SIGMAR1, OPRL1, OPRK1 | S1PR2 181/4885S1PR4 286/4885S1PR1 117/4885 |
| US-20130102571-A1 | SELECTIVE SIGMA-1 RECEPTOR LIGANDS | SIGMAR1, OPRL1, OPRK1 | S1PR2 169/4885S1PR4 251/4885S1PR1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.