SCHEMBL31190891

SCHEMBL31190891

O=C(O)c1ccn2cc(-c3ccccc3-c3ccc(F)cc3F)nc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.44
S1PR3 Q99500 1/20 0.44
FFAR1 O14842 3/20 0.43
KMO O15229 2/20 0.40
KDM4A O75164 1/20 0.40
KDM5A P29375 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
KDM5B Q9UGL1 1/20 0.40
SUV39H2 Q9H5I1 2/20 0.39
TLR9 Q9NR96 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
TP53 P04637 1/20 0.38
MDM2 Q00987 1/20 0.38
CASP6 P55212 1/20 0.38
RAB9A P51151 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
PTGER1 P34995 1/20 0.37
HDAC1 Q13547 1/20 0.37
RORC P51449 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31190893 0.87 ALPL (0.42) S1PR1S1PR3FFAR1SUV39H2TLR9
SCHEMBL16003643 0.84 FFAR1 (0.48) S1PR1S1PR3FFAR1KMOKDM4A
SCHEMBL31190906 0.81 HPGDS (0.42) S1PR1S1PR3FFAR1SUV39H2TLR9
SCHEMBL31190897 0.77 SUV39H2 (0.41) S1PR1S1PR3SUV39H2RAB9AKDM4E
SCHEMBL1457799 0.76 HDAC1 (0.57) TLR9TP53RAB9AKDM4ENPC1
SCHEMBL31190882 0.76 ALPL (0.40) FFAR1SUV39H2TLR9TLR7RAB9A
SCHEMBL31190913 0.76 PADI4 (0.42) KMOKDM4AKDM5AKDM4CKDM5B
SCHEMBL964317 0.73 RAB9A (0.63) TLR9TP53MDM2CASP6RAB9A
Hydrochloric Acid SCHEMBL8874207 0.72 RAB9A (0.61) TLR9TP53MDM2CASP6RAB9A
SCHEMBL1691855 0.71 FFAR1 (0.42) S1PR1S1PR3FFAR1SUV39H2TLR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024220543-A1 NK3 MODULATORS AND USES THEREOF KALLYOPE, INC. (US) 2024-10-24 WO disclosed