Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839623 | 0.81 | NR1H4 (0.41) | NOTUMNR1H4ALOX5MAOAMAOB | |
| SCHEMBL3277352 | 0.81 | ALDH1A1 (0.39) | NOTUMNR1H4ALOX5MAOAMAOB | |
| SCHEMBL31538740 | 0.80 | NR1H4 (0.37) | NOTUMNR1H4ALOX5PTGS1PTGS2 | |
| SCHEMBL31191980 | 0.77 | NOTUM (0.33) | NOTUMALOX5NPC1MEN1KMT2A | |
| SCHEMBL5763911 | 0.77 | NR1H4 (0.62) | NR1H4ALOX5MAOBNPC1RAB9A | |
| SCHEMBL31191921 | 0.77 | NOTUM (0.35) | NOTUM | |
| SCHEMBL31191940 | 0.74 | KMT2A (0.43) | NOTUMNR1H4ALOX5ALBTTR | |
| SCHEMBL16397645 | 0.73 | ALOX5 (0.64) | ALOX5PTGS1PTGS2MAOAMAOB | |
| SCHEMBL212724 | 0.73 | ALOX5 (0.64) | ALOX5PTGS1PTGS2MAOAMAOB | |
| SCHEMBL27845538 | 0.72 | PTGS1 (0.41) | NOTUMPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4703358-A1 | BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF | China Pharmaceutical University (CN) | 2026-03-04 | — | — | EP | disclosed |
| WO-2025092775-A1 | PHTHALAZINONE GSPT1 PROTEIN DEGRADING AGENT AND USE THEREOF | 中国药科大学 | 2025-05-08 | — | — | WO | disclosed |
| CN-119912437-A | Phthalazinone GSPT protein degradation agent and application thereof | 中国药科大学 | 2025-05-02 | — | — | CN | disclosed |
| WO-2024222918-A1 | BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF | 中国药科大学 | 2024-10-31 | — | — | WO | disclosed |