Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.68 |
| ▸ | EDNRA | P25101 | 1/20 | 0.68 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TOP2A | P11388 | 2/20 | 0.65 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | DPP4 | P27487 | 6/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020192 | 0.96 | LMNA (0.64) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377708 | 0.90 | DPP4 (0.66) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377337 | 0.89 | DPP4 (0.65) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377719 | 0.89 | DPP4 (0.65) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11022634 | 0.88 | DPP4 (0.68) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9686951 | 0.88 | KDM4E (0.54) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377364 | 0.88 | DPP4 (0.62) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377621 | 0.88 | DPP4 (0.62) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10377610 | 0.88 | DPP4 (0.62) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9687753 | 0.87 | KDM4E (0.63) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153828-B1 | 1-CYCLOPROPYL-1, 4-DIHYDRO-6-FLUORO-4-OXO-1, 8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS; THEIR DERIVATIVES AND A PROCESS FOR PREPARING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1990-12-27 | — | — | EP | claimed |
| CN-1003236-B | Preparation method of 6, 7-disubstituted-1-cyclopropyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid | 拜尔公司 | 1989-02-08 | — | — | CN | claimed |
| JP-60197686-A | — | — | None | — | — | JP | disclosed |
| JP-60032790-A | — | — | None | — | — | JP | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| EP-1730154-B1 | RIFAMYCIN DERIVATIVES EFFECTIVE AGAINST DRUG-RESISTANT MICROBES | CUMBRE IP VENTURES L P (US) | 2012-10-17 | — | — | EP | disclosed |
| US-8093381-B2 | Method of synthesis of fluoroquinolones | BIOCODEX (FR) | 2012-01-10 | — | — | US | disclosed |
| EP-2138490-B1 | New method for synthesis of fluoroquinolones | BIOCODEX (FR) | 2011-08-31 | — | — | EP | disclosed |
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | BIOCODEX (FR) | 2009-02-26 | — | — | US | disclosed |
| US-7247634-B2 | Rifamycin derivatives effective against drug-resistant microbes | CUMBRE PHARMACEUTICALS INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7238694-B2 | Rifamycin imino derivatives effective against drug-resistant microbes | CUMBRE PHARMACEUTICALS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| CN-86100126-A | 6, the two replacement-1-cyclopropyl of 7--1,4 dihydro-4-oxo-1, the preparation method and the application thereof of 8-naphthyridines-3-carboxylic acid | — | 1986-07-09 | — | — | CN | disclosed |
| EP-0172651-A1 | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | disclosed |
| US-4571396-A | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-02-18 | — | — | US | disclosed |
| EP-0160578-A1 | 1,8-Naphthyridine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-11-06 | — | — | EP | disclosed |
| EP-0159174-A2 | Substituted naphthyridine-, quinoline- and benzoxazine- carboxylic acids as antibacterial agents and processes for their production | WARNER-LAMBERT COMPANY (US) | 1985-10-23 | — | — | EP | disclosed |
| JP-S60197686-A | 1,8-NAPHTHYRIDINE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1985-10-07 | — | — | JP | disclosed |
| EP-0153828-A2 | 1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acids; their derivatives and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-09-04 | — | — | EP | disclosed |
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| JP-S6032790-A | 1,8-NAPHTHYRIDINES | DAINIPPON PHARMACEUT CO LTD | 1985-02-19 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | NQO2, Q6ZSR9, QARS1 | LMNA 2081/4885CYP2C9 109/4885ATP6V1B2 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.