Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.42 |
| ▸ | VCP | P55072 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309319 | 1.00 | MAPT (0.46) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8114008 | 0.90 | PTGER4 (0.41) | MAPTKMT2ASMN1; SMN2MEN1MAPK1 | |
| SCHEMBL31196487 | 0.86 | VCP (0.55) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15099939 | 0.85 | KAT2B (0.46) | MAPTMAPK1L3MBTL1KAT2BALDH1A1 | |
| SCHEMBL31200365 | 0.84 | L3MBTL1 (0.45) | MAPTKMT2AGAAMEN1MAPK1 | |
| SCHEMBL11893762 | 0.84 | MAPT (0.51) | MAPTKMT2ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL11893761 | 0.84 | MAPT (0.51) | MAPTKMT2ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL25232312 | 0.81 | ALDH1A1 (0.52) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25280918 | 0.81 | ALDH1A1 (0.52) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11893596 | 0.81 | MAPT (0.53) | MAPTKMT2AMEN1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| EP-4709722-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233547-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |