Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196594 | 0.85 | KDM4E (0.39) | KMT2AMEN1MAPK1TSHRMAPT | |
| SCHEMBL22247294 | 0.77 | KMO (0.40) | KMT2AMEN1 | |
| SCHEMBL31196325 | 0.76 | HPGD (0.40) | KMT2AMEN1SMN1; SMN2HPGDLMNA | |
| SCHEMBL24737343 | 0.71 | KMT2A (0.39) | KMT2AMEN1TSHRMAPTPOLB | |
| SCHEMBL29880067 | 0.71 | KMT2A (0.39) | KMT2AMEN1TSHRMAPTPOLB | |
| SCHEMBL6182350 | 0.71 | MAPT (0.55) | KMT2AMEN1MAPK1TSHRMAPT | |
| SCHEMBL2705546 | 0.69 | FFAR4 (0.39) | KMT2AMEN1RAB9A | |
| SCHEMBL31196382 | 0.68 | KMO (0.36) | LMNA | |
| SCHEMBL15308686 | 0.68 | MEN1 (0.44) | KMT2AMEN1MAPTALDH1A1CYP2C19 | |
| SCHEMBL31196261 | 0.68 | MEN1 (0.44) | KMT2AMEN1MAPTALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |