Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196382 | 0.88 | KMO (0.36) | PARP10PARP15PARP2CNR2KMO | |
| SCHEMBL31196232 | 0.76 | RIPK1 (0.51) | PARP10PARP15PARP2CNR2CDK1 | |
| SCHEMBL31196165 | 0.76 | RIPK1 (0.51) | PARP10PARP15PARP2CNR2CDK1 | |
| SCHEMBL31196325 | 0.71 | HPGD (0.40) | CNR2KMO | |
| SCHEMBL31196108 | 0.71 | RIPK1 (0.54) | PARP10PARP15CNR2 | |
| SCHEMBL31196507 | 0.71 | RIPK1 (0.54) | PARP10PARP15CNR2 | |
| SCHEMBL31196433 | 0.69 | HPGD (0.40) | PARP10PARP15PARP2CNR2FFAR4 | |
| SCHEMBL16290891 | 0.69 | MCHR1 (0.42) | PARP10PARP15PARP2CDK1CDK2 | |
| SCHEMBL25257074 | 0.66 | KMO (0.51) | KMOLRRK2 | |
| SCHEMBL30547498 | 0.66 | KMO (0.51) | KMOLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |