Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.53 |
| ▸ | TDO2 | P48775 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MECP2 | P51608 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430767 | 0.78 | TDO2 (0.51) | TDO2MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL22637149 | 0.78 | TDO2 (0.51) | TDO2MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7472158 | 0.77 | TDO2 (0.59) | TDO2MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL25094361 | 0.77 | KIF11 (0.47) | TDO2MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL22636714 | 0.76 | MAPK1 (0.44) | TDO2MAPTMEN1L3MBTL1NPC1 | |
| SCHEMBL29430620 | 0.76 | MAPK1 (0.44) | TDO2MAPTMEN1L3MBTL1NPC1 | |
| SCHEMBL19296094 | 0.74 | MAPT (0.43) | MAP4K4TDO2MAPTMKNK2L3MBTL1 | |
| SCHEMBL22637099 | 0.73 | BRD4 (0.40) | TDO2MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL12492122 | 0.73 | CYP3A4 (0.48) | TDO2MAPTMEN1L3MBTL1TSHR | |
| SCHEMBL22637054 | 0.73 | TDO2 (0.56) | TDO2MAPTMEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240376046-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2024-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376046-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | ERAP1, XPO1, RRP15 | MAP4K4 3589/4885TDO2 481/4885MAPT 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.