Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.35 |
| ▸ | TUBB | P07437 | 2/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233283 | 0.81 | KDR (0.39) | KDROGA | |
| SCHEMBL20813390 | 0.79 | KDR (0.39) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL25673701 | 0.76 | CYP3A4 (0.40) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL24067431 | 0.76 | LMNA (0.39) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL8499852 | 0.75 | KDR (0.46) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL13472431 | 0.73 | KMO (0.47) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL17459121 | 0.73 | HCK (0.58) | KDRLCKHCK | |
| SCHEMBL15392867 | 0.71 | CYP3A4 (0.50) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL11179382 | 0.71 | ALDH1A1 (0.51) | KDRCYP3A4CYP2E1CYP2A6ALDH1A1 | |
| SCHEMBL19130973 | 0.70 | CSF1R (0.39) | KDRCYP3A4ALDH1A1LCKL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |