Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205814 | 0.86 | RIPK1 (0.50) | RIPK1HRH3 | |
| SCHEMBL25816590 | 0.85 | RIPK1 (0.45) | RIPK1HRH3KDM1AMEN1CYP2D6 | |
| SCHEMBL25816557 | 0.83 | RIPK1 (0.48) | RIPK1HRH3KDM1A | |
| SCHEMBL31205558 | 0.80 | RIPK1 (0.46) | RIPK1HRH3KDM1AMEN1CYP2D6 | |
| SCHEMBL25818710 | 0.80 | RIPK1 (0.46) | RIPK1HRH3KDM1A | |
| SCHEMBL31205954 | 0.80 | RIPK1 (0.44) | RIPK1HRH3KDM1AMEN1CYP2D6 | |
| SCHEMBL25188639 | 0.78 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL25559419 | 0.78 | RIPK1 (0.43) | RIPK1 | |
| Trifluoroacetic Acid SCHEMBL30339113 | 0.78 | RIPK1 (0.42) | RIPK1HRH3KDM1A | |
| Trifluoroacetic Acid SCHEMBL29048342 | 0.77 | RIPK1 (0.46) | RIPK1HRH3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |