Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22895800 | 1.00 | IDH1 (0.41) | IDH1ALDH1A1COMTMAPTGABRA1 | |
| SCHEMBL16877063 | 0.79 | HSP90AA1 (0.46) | ALDH1A1COMTMAPTKDM4ENPC1 | |
| SCHEMBL16505223 | 0.77 | ALDH1A1 (0.43) | IDH1ALDH1A1COMTMAPTCYP1A2 | |
| SCHEMBL18422770 | 0.75 | ALDH1A1 (0.41) | IDH1ALDH1A1COMTMAPTCYP1A2 | |
| SCHEMBL15726348 | 0.75 | COMT (0.47) | ALDH1A1COMTMAPTCYP1A2CYP3A4 | |
| SCHEMBL27315070 | 0.73 | POLB (0.42) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL18171776 | 0.73 | GABRA1 (0.41) | ALDH1A1MAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL17601377 | 0.72 | IDO1 (0.44) | IDH1GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL29174633 | 0.72 | ALDH1A1 (0.42) | ALDH1A1COMTMAPTCYP1A2CYP3A4 | |
| SCHEMBL30725463 | 0.72 | ALDH1A1 (0.42) | ALDH1A1COMTMAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |