Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.34 |
| ▸ | GSK3B | P49841 | 6/20 | 0.34 |
| ▸ | WNT1 | P04628 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205954 | 0.83 | RIPK1 (0.44) | RIPK1DYRK1AGSK3BWNT1MEN1 | |
| SCHEMBL25816648 | 0.82 | DYRK1A (0.39) | RIPK1DYRK1AGSK3BWNT1HRH3 | |
| SCHEMBL20580062 | 0.81 | ALDH1A1 (0.32) | RIPK1KMT2A | |
| SCHEMBL31200045 | 0.79 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL31200019 | 0.78 | RIPK1 (0.37) | RIPK1ABL1 | |
| SCHEMBL18921388 | 0.78 | RIPK1 (0.35) | RIPK1 | |
| SCHEMBL31200053 | 0.78 | RIPK1 (0.35) | RIPK1 | |
| SCHEMBL31200034 | 0.78 | RIPK1 (0.37) | RIPK1 | |
| SCHEMBL31205899 | 0.77 | RIPK1 (0.40) | RIPK1MEN1CYP2D6KMT2AKDM1A | |
| SCHEMBL31205558 | 0.76 | RIPK1 (0.46) | RIPK1DYRK1AGSK3BWNT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233544-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |