SCHEMBL31207413

SCHEMBL31207413

Cc1nc2cc(-c3cc(F)c(N)cc3Cl)ccc2[nH]1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 3/20 0.40
ALDH1A1 P00352 4/20 0.39
POLB P06746 4/20 0.39
KDM4E B2RXH2 4/20 0.39
MAPT P10636 4/20 0.39
NPC1 O15118 4/20 0.39
RAB9A P51151 4/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
GFER P55789 2/20 0.39
GLA P06280 1/20 0.39
GAA P10253 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
HPGD P15428 2/20 0.37
SMN1; SMN2 Q16637 3/20 0.36
HAVCR2 Q8TDQ0 1/20 0.35
BRD4 O60885 3/20 0.35
PRKCI P41743 1/20 0.34
USP7 Q93009 1/20 0.34
CYP1A1 P04798 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31207416 1.00 TRPV1 (0.40) TRPV1ALDH1A1POLBKDM4EMAPT
SCHEMBL18761580 0.78 ALDH1A1 (0.49) TRPV1ALDH1A1POLBKDM4EMAPT
SCHEMBL30296235 0.74 L3MBTL1 (0.49) ALDH1A1KDM4EMAPTNPC1RAB9A
SCHEMBL14014551 0.74 MAPT (0.49) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL25457211 0.73 RAB9A (0.53) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL31207402 0.73 RAB9A (0.40) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL10299633 0.73 MEN1 (0.47) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL31207417 0.72 KMT2A (0.41) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL12052868 0.72 POLB (0.51) ALDH1A1POLBKDM4EMAPTNPC1
SCHEMBL17450161 0.72 MEN1 (0.46) ALDH1A1POLBKDM4EMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4702021-A1 COMPOUNDS CAPABLE OF MODULATING GPR65 Pathios Therapeutics Limited (GB) 2026-03-04 EP disclosed
WO-2024224064-A1 COMPOUNDS CAPABLE OF MODULATING GPR65 Pathios Therapeutics Limited (GB) 2024-10-31 WO disclosed