Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120759 | 0.94 | GRM2 (0.40) | GRM2PDE4BCYP3A4RXRA | |
| SCHEMBL3129699 | 0.88 | RXRA (0.42) | LMNAPDE4BPDE4DRXRA | |
| SCHEMBL3216620 | 0.87 | HDAC6 (0.34) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3118000 | 0.87 | GRM2 (0.44) | GRM2LMNAPOLBMAPTPDE4B | |
| SCHEMBL3201568 | 0.86 | GRM2 (0.40) | GRM2LMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL3123568 | 0.84 | ALDH1A1 (0.40) | L3MBTL1CYP1A2TSHRCYP2C19POLB | |
| SCHEMBL3132918 | 0.82 | RXRA (0.45) | GRM2TSHRPDE4BKMT2APDE4A | |
| SCHEMBL3133648 | 0.82 | RXRA (0.45) | PDE4BPDE4DRXRA | |
| SCHEMBL3133561 | 0.81 | GRM2 (0.42) | GRM2LMNAPOLBMAPTPDE4B | |
| SCHEMBL3128993 | 0.80 | HRH4 (0.39) | LMNATSHRPOLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |