Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16302366 | 0.87 | CA12 (0.51) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL14439972 | 0.84 | CA12 (0.49) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL9288893 | 0.83 | CYP3A4 (0.47) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL849917 | 0.83 | CA12 (0.48) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL25620110 | 0.83 | CA12 (0.48) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL16991873 | 0.82 | ALDH1A1 (0.49) | CA12CA1CA9CYP17A1KDM4E | |
| SCHEMBL28895283 | 0.82 | CA12 (0.42) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL31206290 | 0.82 | CA12 (0.42) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL28895279 | 0.81 | CA12 (0.41) | CA12CA1CA9CYP17A1LCK | |
| SCHEMBL7477384 | 0.80 | CA12 (0.48) | CA12CA1CA9CYP17A1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |