Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RHEB | Q15382 | 5/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 3/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31215308 | 0.90 | THRA (0.46) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215319 | 0.90 | THRA (0.48) | THRATHRBRHEBNPC1SRD5A2 | |
| SCHEMBL31215276 | 0.88 | SRD5A2 (0.58) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215302 | 0.84 | THRA (0.43) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215282 | 0.82 | MRGPRX4 (0.42) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215307 | 0.81 | RHEB (0.51) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215280 | 0.80 | THRA (0.46) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215274 | 0.80 | RHEB (0.50) | THRATHRBRHEBSRD5A2GRIN1 | |
| SCHEMBL31215309 | 0.80 | SRD5A2 (0.49) | THRATHRBRHEBNR4A2SRD5A2 | |
| SCHEMBL31215292 | 0.79 | THRA (0.48) | THRATHRBRHEBSRD5A2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894802-A | Selective THR beta agonist compound and application thereof | 山东第一医科大学(山东省医学科学院) | 2024-11-05 | — | — | CN | disclosed |