Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299321 | 0.82 | DRD4 (0.50) | DRD4SIGMAR1TMEM97 | |
| SCHEMBL3122265 | 0.81 | KIF11 (0.39) | DRD4SIGMAR1TMEM97CARM1PRMT6 | |
| SCHEMBL31379708 | 0.81 | SLC6A4 (0.46) | NAAACTSKP2RX7 | |
| SCHEMBL2299165 | 0.79 | CARM1 (0.56) | CARM1PRMT6 | |
| SCHEMBL3128435 | 0.78 | SLC6A4 (0.45) | DRD4SIGMAR1TMEM97CARM1PRMT6 | |
| SCHEMBL2299162 | 0.77 | CARM1 (0.56) | DRD4SIGMAR1HCRTR1HCRTR2CARM1 | |
| SCHEMBL2300932 | 0.77 | SCN9A (0.42) | NAAACTSKP2RX7 | |
| SCHEMBL3118087 | 0.75 | SIGMAR1 (0.36) | DRD4SIGMAR1TMEM97CARM1PRMT6 | |
| SCHEMBL2296456 | 0.73 | CARM1 (0.54) | NAAADRD4SIGMAR1TMEM97CARM1 | |
| SCHEMBL3126964 | 0.72 | CARM1 (0.55) | DRD4SIGMAR1TMEM97CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |