Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 18/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128435 | 0.84 | SLC6A4 (0.45) | DRD4SIGMAR1TMEM97DRD3DRD5 | |
| SCHEMBL3122265 | 0.84 | KIF11 (0.39) | DRD4SIGMAR1TMEM97DRD3DRD5 | |
| SCHEMBL3118087 | 0.83 | SIGMAR1 (0.36) | DRD4SIGMAR1TMEM97DRD3DRD5 | |
| SCHEMBL3121802 | 0.82 | NAAA (0.42) | DRD4SIGMAR1TMEM97 | |
| SCHEMBL2302468 | 0.81 | SLC6A2 (0.61) | DRD4SIGMAR1TMEM97DRD3DRD5 | |
| SCHEMBL3126964 | 0.79 | CARM1 (0.55) | DRD4SIGMAR1TMEM97SLC6A2SLC6A4 | |
| SCHEMBL3121141 | 0.78 | CARM1 (0.51) | DRD4SIGMAR1DRD3DRD5SLC6A2 | |
| SCHEMBL3116258 | 0.78 | IDO1 (0.42) | DRD4SIGMAR1TMEM97DRD3SLC6A2 | |
| SCHEMBL9434989 | 0.77 | CA1 (0.41) | DRD4DRD3DRD5SLC6A2SLC6A4 | |
| SCHEMBL3126431 | 0.77 | HTR1A (0.37) | DRD4SIGMAR1TMEM97DRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |