SCHEMBL31221963

SCHEMBL31221963

C=Cc1ncc(NC(=O)OC(C)(C)C)cc1F

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.44
▸ RORC P51449 5/20 0.43
▸ ITK Q08881 3/20 0.38
▸ EGFR P00533 2/20 0.38
▸ NAMPT P43490 1/20 0.38
▸ EGLN2 Q96KS0 2/20 0.37
▸ MAP4K4 O95819 1/20 0.37
▸ AR P10275 1/20 0.37
▸ CYP17A1 P05093 2/20 0.36
▸ MAPKAPK2 P49137 1/20 0.35
▸ F13A1 P00488 1/20 0.35
▸ TGM2 P21980 1/20 0.35
▸ TGM1 P22735 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30954931 0.85 RORC (0.41) SYKRORCITKEGFRNAMPT
SCHEMBL31221957 0.84 MAPKAPK2 (0.40) SYKRORCNAMPTMAP4K4AR
SCHEMBL15081332 0.81 SYK (0.45) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL29813612 0.81 SYK (0.45) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL30004261 0.80 SYK (0.44) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL29509761 0.80 SYK (0.44) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL25898751 0.80 SYK (0.44) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL2015768 0.80 SYK (0.44) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL29178680 0.80 SYK (0.44) SYKRORCNAMPTEGLN2MAP4K4
SCHEMBL25394963 0.79 BTK (0.37) SYKITKEGFRMAP4K4TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250197384-A1 AZOLE COMPOUND AND ANTIFUNGAL AGENT NIHON NOHYAKU CO., LTD. (JP) 2025-06-19 — — US disclosed
EP-4495114-A1 AZOLE COMPOUND AND ANTIFUNGAL AGENT Nihon Nohyaku Co., Ltd. (JP) 2025-01-22 — — EP disclosed
CN-118922417-A Azole compounds and antifungal agents 日本农药株式会社 2024-11-08 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250197384-A1 AZOLE COMPOUND AND ANTIFUNGAL AGENT CBR3, ERG28, CBR1 SYK 1141/4885RORC 459/4885ITK 1965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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