SCHEMBL31228124

SCHEMBL31228124

Nc1ncnc2c1ccn2[C@@H]1O[C@](CF)(COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1O

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 17/20 0.46
WDR77 Q9BQA1 15/20 0.46
ADK P55263 1/20 0.45
METTL3 Q86U44 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21332251 0.78 AHCY (0.54) PRMT5WDR77
SCHEMBL29770567 0.78 AHCY (0.54) PRMT5WDR77
SCHEMBL31228148 0.77 PRMT5 (0.38) PRMT5WDR77METTL3
SCHEMBL31228134 0.77 ADK (0.55) PRMT5WDR77ADKMETTL3
SCHEMBL19221820 0.77 AHCY (0.53) PRMT5WDR77
SCHEMBL18049469 0.76 P2RY6 (0.40)
SCHEMBL18049482 0.76 P2RY6 (0.40)
SCHEMBL25400561 0.76 P2RY6 (0.37)
SCHEMBL26124640 0.76 P2RY6 (0.37)
SCHEMBL26135853 0.75 PDE2A (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705313-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS The Scripps Research Institute (US) 2026-03-11 EP disclosed
WO-2024227159-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2024-10-31 WO disclosed