SCHEMBL31228148

SCHEMBL31228148

CC(=O)O[C@H]1[C@H](n2ccc3c(Cl)ncnc32)O[C@](CF)(COCc2ccccc2)[C@H]1OCc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 9/20 0.38
WDR77 Q9BQA1 9/20 0.38
ACHE P22303 3/20 0.35
BCHE P06276 1/20 0.33
ACACB O00763 2/20 0.33
PDE2A O00408 1/20 0.31
NNMT P40261 2/20 0.31
SLC29A1 Q99808 1/20 0.31
METTL3 Q86U44 1/20 0.31
METTL14 Q9HCE5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20724556 0.81 ACHE (0.47) ACHEBCHEPDE2A
SCHEMBL26123590 0.81 ST6GAL1 (0.40) SLC29A1
SCHEMBL26123588 0.81 ST6GAL1 (0.40) SLC29A1
SCHEMBL23243930 0.80 ACHE (0.42) ACHEBCHEPDE2ASLC29A1
SCHEMBL19861796 0.80 TDP1 (0.39) SLC29A1
SCHEMBL21332426 0.78 ACHE (0.42) ACHEBCHEPDE2A
SCHEMBL23996233 0.78 TDP1 (0.34)
SCHEMBL17958879 0.78 TDP1 (0.34)
SCHEMBL31228124 0.77 PRMT5 (0.46) PRMT5WDR77METTL3
SCHEMBL26122701 0.76 P2RY6 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705313-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS The Scripps Research Institute (US) 2026-03-11 EP disclosed
WO-2024227159-A2 4'-SUBSTITUTED NUCLEOSIDES AND NUCLEOTIDES AS ANTIVIRAL AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2024-10-31 WO disclosed