Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL31228168 | 1.00 | KDM4E (0.45) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| Acetic Acid SCHEMBL28257345 | 0.89 | KDM4E (0.49) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL14665069 | 0.87 | KDM4E (0.51) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| Glycine SCHEMBL28224417 | 0.85 | L3MBTL1 (0.43) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| Glycine SCHEMBL28922132 | 0.84 | SMN1; SMN2 (0.48) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| Sulfuric Acid SCHEMBL17273294 | 0.83 | L3MBTL1 (0.46) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| Glycine SCHEMBL28864321 | 0.81 | SMN1; SMN2 (0.48) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL28389799 | 0.81 | L3MBTL1 (0.47) | KDM4EL3MBTL1CYP2D6MAPTKMT2A | |
| Glycine SCHEMBL31228162 | 0.79 | SMN1; SMN2 (0.40) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL17385605 | 0.79 | KDM4E (0.50) | KDM4EL3MBTL1SMN1; SMN2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118718762-A | Amino ion liquid grafted polyamide thin layer composite nanofiltration membrane and preparation method thereof | 杭州师范大学 | 2024-10-01 | — | — | CN | disclosed |