Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113866 | 0.78 | SIGMAR1 (0.45) | MAOAMAOBTSHRNPSR1SIGMAR1 | |
| SCHEMBL29392702 | 0.78 | SIGMAR1 (0.45) | MAOAMAOBTSHRNPSR1SIGMAR1 | |
| SCHEMBL2023897 | 0.76 | MAOA (0.42) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL24181279 | 0.75 | CYP2D6 (0.37) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL31069756 | 0.75 | MAOB (0.37) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL31205377 | 0.75 | SIGMAR1 (0.40) | MAOAMAOBTSHRSIGMAR1DRD2 | |
| SCHEMBL28860430 | 0.74 | HTR2A (0.39) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL7621490 | 0.74 | CYP2D6 (0.36) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL22032186 | 0.73 | SIGMAR1 (0.44) | MAOAMAOBCYP2D6TSHRCYP2C19 | |
| SCHEMBL1441712 | 0.73 | PKM (0.41) | MAOAMAOBCYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126006-A | Gem difluoro dihydrobenzofuran derivative and preparation method thereof | 贵州理工学院 | 2024-06-04 | — | — | CN | claimed |
| CN-118126006-A | Gem difluoro dihydrobenzofuran derivative and preparation method thereof | 贵州理工学院 | 2024-06-04 | — | — | CN | disclosed |
| CN-118126006-A | Gem difluoro dihydrobenzofuran derivative and preparation method thereof | 贵州理工学院 | 2024-06-04 | — | — | CN | disclosed |
| CN-118126006-A | Gem difluoro dihydrobenzofuran derivative and preparation method thereof | 贵州理工学院 | 2024-06-04 | — | — | CN | disclosed |
| EP-4277901-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics, Inc. (US) | 2023-11-22 | — | — | EP | disclosed |
| WO-2023200441-A1 | ANTIVIRAL HETEROCYCLIC COMPOUNDS | ENANTA PHARMACEUTICALS, INC. (US) | 2023-10-19 | — | — | WO | disclosed |
| WO-2022152821-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-07-21 | — | — | WO | disclosed |
| CN-109867645-B | Synthetic method of 2, 2-difluoro-2, 3-dihydro-substituted benzofuran compound | 中国医学科学院药物研究所 | 2021-09-14 | — | — | CN | disclosed |
| US-7648742-B2 | Difluorosubstituted heterocyclic compounds and the use thereof in the form of components in liquid crystalline media | MERCK PATENT GMBH (DE) | 2010-01-19 | — | — | US | disclosed |
| US-7648742-B2 | Difluorosubstituted heterocyclic compounds and the use thereof in the form of components in liquid crystalline media | MERCK PATENT GMBH (DE) | 2010-01-19 | — | — | US | disclosed |
| US-7648742-B2 | Difluorosubstituted heterocyclic compounds and the use thereof in the form of components in liquid crystalline media | MERCK PATENT GMBH (DE) | 2010-01-19 | — | — | US | disclosed |
| US-20080071097-A1 | Difluorosubstituted Heterocyclic Compounds and the Use Thereof in the Form of Components in Liquid Crystalline Media | MERCK PATENT GMBH (DE) | 2008-03-20 | — | — | US | disclosed |
| US-20080071097-A1 | Difluorosubstituted Heterocyclic Compounds and the Use Thereof in the Form of Components in Liquid Crystalline Media | MERCK PATENT GMBH (DE) | 2008-03-20 | — | — | US | disclosed |
| US-20080071097-A1 | Difluorosubstituted Heterocyclic Compounds and the Use Thereof in the Form of Components in Liquid Crystalline Media | MERCK PATENT GMBH (DE) | 2008-03-20 | — | — | US | disclosed |
| WO-2006012965-A1 | DIFLUOROSUBSTITUTED HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN THE FORM OF COMPONENTS IN LIQUID CRYSTALLINE MEDIA | MERCK PATENT GMBH (DE) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080071097-A1 | Difluorosubstituted Heterocyclic Compounds and the Use Thereof in the Form of Components in Liquid Crystalline Media | C1S, CCND3, CCND2 | MAOA 603/4885MAOB 131/4885CYP2D6 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.