Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 3/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228227 | 1.00 | YAP1 (0.39) | YAP1GHSRKLK7GPR119PARP1 | |
| SCHEMBL31228531 | 0.92 | KLK7 (0.39) | YAP1GHSRKLK7GPR119PARP1 | |
| SCHEMBL31228285 | 0.90 | KLK7 (0.37) | GHSRKLK7GPR119PARP1MEN1 | |
| SCHEMBL31153940 | 0.86 | YAP1 (0.39) | YAP1GHSRKLK7GPR119PARP1 | |
| SCHEMBL31228368 | 0.86 | MAPT (0.40) | GHSRKLK7GPR119PARP1MEN1 | |
| SCHEMBL31228414 | 0.82 | KMT2A (0.32) | KMT2ASMN1; SMN2 | |
| SCHEMBL31228393 | 0.81 | KLK7 (0.44) | GHSRKLK7PARP1MEN1MAPT | |
| SCHEMBL31228493 | 0.81 | KLK7 (0.46) | KLK7GPR119PARP1KMT2AJAK2 | |
| SCHEMBL31228337 | 0.81 | KLK7 (0.46) | KLK7GPR119PARP1KMT2AJAK2 | |
| SCHEMBL31228495 | 0.81 | KLK7 (0.46) | KLK7GPR119PARP1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |