Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421947 | 0.85 | POLB (0.41) | ALDH1A1LMNAKDM4ETSHRCYP3A4 | |
| SCHEMBL421948 | 0.85 | POLB (0.41) | ALDH1A1LMNAKDM4ETSHRCYP3A4 | |
| SCHEMBL9733498 | 0.85 | TSHR (0.40) | ALDH1A1KDM4ETSHRTDP1CNR2 | |
| SCHEMBL8936121 | 0.83 | MAOB (0.47) | ALDH1A1MAOBLMNAKDM4ECTSB | |
| SCHEMBL8936116 | 0.83 | MAOB (0.47) | ALDH1A1MAOBLMNAKDM4ECTSB | |
| SCHEMBL17986869 | 0.80 | MAOB (0.42) | ALDH1A1MAOBLMNAKDM4ECTSB | |
| SCHEMBL27968570 | 0.79 | ALDH1A1 (0.56) | ALDH1A1MAOBLMNAKDM4ECTSB | |
| SCHEMBL5703569 | 0.73 | NR1D1 (0.53) | ALDH1A1MAOBCTSBPYCR1MEN1 | |
| SCHEMBL20428928 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MAOBLMNACTSBTSHR | |
| SCHEMBL11228448 | 0.71 | HDAC3 (0.41) | ALDH1A1TSHRMEN1KMT2ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |