Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29560191 | 0.81 | SMN1; SMN2 (0.45) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL20129622 | 0.81 | MEN1 (0.45) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL20129642 | 0.81 | MEN1 (0.45) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL6475389 | 0.80 | PREP (0.49) | NPSR1PREP | |
| SCHEMBL6484219 | 0.80 | PREP (0.49) | NPSR1PREP | |
| SCHEMBL6475398 | 0.80 | PREP (0.49) | NPSR1PREP | |
| SCHEMBL3637452 | 0.79 | FKBP1A (0.48) | TMEM97SIGMAR1PREP | |
| SCHEMBL15185033 | 0.79 | NPC1 (0.43) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL29510871 | 0.78 | PDK1 (0.44) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL31287316 | 0.77 | ABHD6 (0.43) | PDK1PDK2PDK3PDK4PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |