Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31232772 | 0.80 | MAPT (0.57) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL29078390 | 0.78 | ALDH1A1 (0.72) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL1646553 | 0.78 | MAPT (0.59) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL30585250 | 0.78 | LMNA (0.54) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL30585248 | 0.77 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL5741339 | 0.75 | SIRT6 (0.62) | LMNAALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL519813 | 0.72 | IGF1R (0.65) | LMNAALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL519460 | 0.72 | IGF1R (0.65) | LMNAALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL519461 | 0.72 | IGF1R (0.65) | LMNAALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL1127229 | 0.71 | KMT2A (0.66) | LMNAALDH1A1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233922-A2 | PYRIDINE-PIPERAZINE-BASED SCAFFOLDS AS HIGHLY POTENT AND SELECTIVE NEUROLYSIN ACTIVATORS | TEXAS TECH UNIVERSITY SYSTEM (US) | 2024-11-14 | — | — | WO | disclosed |