Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TUBB | P07437 | 1/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783262 | 0.92 | KDM4E (0.86) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL29377022 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL312663 | 0.91 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10739914 | 0.91 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL48145 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL11185030 | 0.91 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL9745354 | 0.90 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL11193870 | 0.90 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL9745337 | 0.90 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL312186 | 0.90 | KDM4E (0.86) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093381-B2 | Method of synthesis of fluoroquinolones | BIOCODEX (FR) | 2012-01-10 | — | — | US | disclosed |
| EP-2138490-B1 | New method for synthesis of fluoroquinolones | BIOCODEX (FR) | 2011-08-31 | — | — | EP | disclosed |
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | BIOCODEX (FR) | 2009-02-26 | — | — | US | disclosed |
| EP-0828715-B1 | N-OXIDES AS ANTIBACTERIAL AGENTS | BAYER AG (DE) | 2001-08-16 | — | — | EP | disclosed |
| US-6114351-A | N-oxides as antibacterial agents | BAYER AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| US-5210193-A | Bactericide | AMERICAN CYANAMID COMPANY (US) | 1993-05-11 | — | — | US | disclosed |
| US-4940710-A | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0205029-A2 | Quinolinecarboxylic acids with an antibacterial activity | BAYER AG (DE) | 1986-12-17 | — | — | EP | disclosed |
| EP-0115049-B1 | 1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-(1-IMIDAZOLYL)-4-OXOQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR PREPARING THE SAME AND ANTI-MICROBIAL COMPOSITIONS | KANEBO, LTD. (JP) | 1986-09-10 | — | — | EP | disclosed |
| US-4530930-A | Antimicrobial 1-ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4-oxoquinoline-3-carboxylic acid derivatives | KANEBO, LTD. (JP) | 1985-07-23 | — | — | US | disclosed |
| EP-0115049-A1 | 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4-oxoquinoline-3-carboxylic acid derivatives, process for preparing the same and anti-microbial compositions | KANEBO, LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | NQO2, Q6ZSR9, QARS1 | KDM4E 2435/4885ALDH1A1 3146/4885HPGD 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.