Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241547 | 0.84 | BRD4 (0.47) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3129083 | 0.82 | BRD4 (0.43) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3124602 | 0.77 | HSD17B10 (0.51) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3121980 | 0.76 | HSD17B10 (0.46) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3125982 | 0.74 | ALDH1A1 (0.46) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3129080 | 0.74 | BRD4 (0.43) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3127066 | 0.65 | AR (0.49) | ALDH1A1PRKDCARLMNA | |
| SCHEMBL4973553 | 0.64 | FFAR1 (0.57) | — | |
| SCHEMBL3119485 | 0.64 | PIK3CA (0.48) | BRD4PDE2AGRM5HSD17B10ALDH1A1 | |
| SCHEMBL3265059 | 0.64 | PIK3CA (0.43) | BRD4GRM5HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |