Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124652 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL28226906 | 0.69 | ALDH1A1 (0.77) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL220303 | 0.68 | ALDH1A1 (0.66) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL2176945 | 0.67 | L3MBTL3 (0.45) | ALDH1A1TSHRMAPK1LMNANOTUM | |
| SCHEMBL11091530 | 0.67 | MAPT (0.59) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL12969070 | 0.67 | ALDH1A1 (0.56) | ALDH1A1TSHRMAPK1LMNANOTUM | |
| SCHEMBL18998073 | 0.66 | TSHR (0.68) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL21231614 | 0.66 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL11709526 | 0.65 | DHFR (0.54) | ALDH1A1TSHRMEN1MAPK1KMT2A | |
| SCHEMBL26706279 | 0.64 | ALDH1A1 (0.76) | ALDH1A1KMT2ALMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |