Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718308 | 0.83 | SLC18A3 (0.57) | SLC18A3SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30368779 | 0.83 | HTR1A (0.61) | SLC18A3SIGMAR1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL233327 | 0.83 | HTR1A (0.61) | SLC18A3SIGMAR1HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL30010417 | 0.81 | HTR2C (0.61) | SLC18A3SIGMAR1HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL1765243 | 0.81 | HTR2C (0.61) | SLC18A3SIGMAR1HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7617662 | 0.81 | SLC18A3 (0.55) | SLC18A3SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21527353 | 0.77 | CHRNA1 (0.49) | HTR1ASLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL12489074 | 0.77 | DRD2 (0.51) | SLC18A3SIGMAR1HTR2CJAK2JAK3 | |
| SCHEMBL3333986 | 0.73 | HTR1A (0.50) | HTR1ASLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL29698867 | 0.73 | HTR1A (0.50) | HTR1ASLC6A2SLC6A4SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |