Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399583 | 0.89 | MKNK1 (0.40) | MKNK1MKNK2LIMK1PRMT5DHODH | |
| SCHEMBL27399603 | 0.87 | MKNK1 (0.40) | MKNK1MKNK2LIMK1PRMT5DHODH | |
| SCHEMBL27397409 | 0.85 | PKMYT1 (0.42) | MKNK1MKNK2PRMT5DHODHPARP1 | |
| SCHEMBL30905534 | 0.85 | PKMYT1 (0.42) | MKNK1MKNK2PRMT5DHODHPARP1 | |
| SCHEMBL27399933 | 0.84 | PRMT5 (0.41) | MKNK1MKNK2LIMK1PRMT5DHODH | |
| SCHEMBL27399014 | 0.83 | LCK (0.51) | MKNK1MKNK2LIMK1PRMT5DHODH | |
| SCHEMBL27399330 | 0.83 | DHODH (0.39) | MKNK1MKNK2LIMK1PRMT5DHODH | |
| SCHEMBL27397408 | 0.83 | IKBKB (0.41) | MKNK1MKNK2PARP1LMNAKDM4E | |
| SCHEMBL30905539 | 0.83 | IKBKB (0.41) | MKNK1MKNK2PARP1LMNAKDM4E | |
| SCHEMBL27399919 | 0.83 | MKNK1 (0.38) | MKNK1MKNK2LIMK1PRMT5DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |