Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.32 |
| ▸ | PDXK | O00764 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL25341248 | 1.00 | NQO2 (0.36) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL18495782 | 0.98 | NQO2 (0.38) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15322103 | 0.81 | KDM4E (0.42) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3842270 | 0.79 | KDM4E (0.41) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL18507605 | 0.79 | HPGD (0.36) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11207268 | 0.78 | NPC1 (0.31) | KDM4EALDH1A1 | |
| SCHEMBL28752069 | 0.76 | NQO2 (0.35) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL18507603 | 0.76 | KDM4E (0.34) | NQO2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2877344 | 0.73 | LMNA (0.37) | LMNA | |
| SCHEMBL9671256 | 0.73 | CA1 (0.35) | ALDH1A1HPGDHSD17B10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136577-A1 | HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS | C4X DISCOVERY LIMITED (GB) | 2025-05-01 | — | — | US | disclosed |
| CN-119095837-A | Heterocyclic derivatives as MALT1 inhibitors | 希四克斯探索有限公司 | 2024-12-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136577-A1 | HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS | MALT1, SQSTM1, FKBP1A | NQO2 1331/4885KDM4E 1395/4885ALDH1A1 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.