Luteolin

Luteolin

SCHEMBL31258014

O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12.[N]

nearest known ligand 0.97

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLH Q9Y253 8/20 0.97
MEN1 O00255 6/20 0.97
MAPT P10636 6/20 0.97
KMT2A Q03164 6/20 0.97
CYP1B1 Q16678 6/20 0.97
ALDH1A1 P00352 5/20 0.97
ABCB1 P08183 5/20 0.97
KDM4E B2RXH2 5/20 0.97
CYP3A4 P08684 5/20 0.97
HSD17B10 Q99714 5/20 0.97
CYP1A1 P04798 5/20 0.97
CYP1A2 P05177 5/20 0.97
HPGD P15428 4/20 0.97
ALOX15 P16050 4/20 0.97
FTO Q9C0B1 4/20 0.97
XDH P47989 4/20 0.97
HDAC6 Q9UBN7 4/20 0.97
IP6K2 Q9UHH9 4/20 0.97
CYP2C9 P11712 4/20 0.97
CYP2C19 P33261 4/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Luteolin SCHEMBL30045580 0.98 POLH (1.00) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL29352380 0.98 POLH (1.00) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL28256564 0.98 POLH (1.00) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL29376494 0.98 POLH (1.00) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL20426 0.98 POLH (1.00) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL31678931 0.97 POLH (0.97) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL31542150 0.97 POLH (0.97) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL1659262 0.97 POLH (0.97) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL31539190 0.97 POLH (0.97) POLHMEN1MAPTKMT2ACYP1B1
Luteolin SCHEMBL31168048 0.97 POLH (0.97) POLHMEN1MAPTKMT2ACYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119039281-A Preparation method and application of luteolin nitrogen mustard derivative 黑龙江八一农垦大学 2024-11-29 CN claimed
CN-119039281-A Preparation method and application of luteolin nitrogen mustard derivative 黑龙江八一农垦大学 2024-11-29 CN disclosed
CN-119039281-A Preparation method and application of luteolin nitrogen mustard derivative 黑龙江八一农垦大学 2024-11-29 CN disclosed
CN-119039281-A Preparation method and application of luteolin nitrogen mustard derivative 黑龙江八一农垦大学 2024-11-29 CN disclosed