Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31257959 | 1.00 | ROCK2 (0.39) | ROCK2CYP19A1MALT1TRPV1CA2 | |
| SCHEMBL24131486 | 1.00 | ROCK2 (0.39) | ROCK2CYP19A1MALT1TRPV1CA2 | |
| SCHEMBL6377640 | 0.81 | ROCK2 (0.39) | ROCK2CYP19A1CA2RIPK1DRD3 | |
| SCHEMBL31258118 | 0.81 | ROCK2 (0.39) | ROCK2CYP19A1CA2RIPK1DRD3 | |
| SCHEMBL27526641 | 0.81 | DRD3 (0.49) | DRD3 | |
| SCHEMBL27885522 | 0.81 | MALT1 (0.38) | CYP19A1MALT1CA2DRD3HTR7 | |
| SCHEMBL31258122 | 0.77 | MTNR1A (0.56) | ROCK2CYP19A1 | |
| SCHEMBL31258111 | 0.77 | MTNR1A (0.56) | ROCK2CYP19A1 | |
| SCHEMBL833089 | 0.76 | NISCH (0.42) | — | |
| Hydrochloric Acid SCHEMBL31258028 | 0.76 | MTNR1A (0.55) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698529-A1 | BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2026-02-25 | — | — | EP | disclosed |
| WO-2024220173-A1 | BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2024-10-24 | — | — | WO | disclosed |