Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.41 |
| ▸ | THRB | P10828 | 7/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22632611 | 1.00 | THRA (0.41) | THRATHRBPKMPOLBMEN1 | |
| SCHEMBL16043830 | 0.81 | CYP19A1 (0.46) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL22632750 | 0.79 | THRB (0.57) | THRATHRBPKM | |
| SCHEMBL31258407 | 0.79 | THRB (0.57) | THRATHRBPKM | |
| SCHEMBL22632598 | 0.75 | PDE7A (0.44) | THRATHRBPKMMEN1KMT2A | |
| SCHEMBL38661136 | 0.75 | PDE7A (0.44) | THRATHRBPKMMEN1KMT2A | |
| SCHEMBL29414801 | 0.74 | THRA (0.42) | THRATHRBPKMPOLBMEN1 | |
| SCHEMBL282518 | 0.74 | RORC (0.64) | THRATHRB | |
| SCHEMBL22897658 | 0.74 | MAPT (0.49) | POLBMEN1KMT2ALMNATDP1 | |
| SCHEMBL1181428 | 0.74 | MEN1 (0.58) | POLBMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4523692-A2 | MODULATORS OF THR-SS AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| EP-3965884-B1 | MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP | ALIGOS THERAPEUTICS INC (US) | 2025-01-15 | — | — | EP | disclosed |