SCHEMBL31258656

SCHEMBL31258656

Clc1ccc(-n2cncn2)c(Br)c1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
APOBEC3A P31941 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.42
GRM7 Q14831 1/20 0.42
RAB9A P51151 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
HSP90AA1 P07900 1/20 0.41
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17295794 1.00 CRHBP (0.47) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL17242393 0.79 APOBEC3A (0.50) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL29758077 0.79 KDM4E (0.50) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL13749025 0.79 LMNA (0.39) CRHBPCRHR2KMT2AMEN1KDM4E
SCHEMBL7435397 0.79 KDM4E (0.50) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL6926426 0.79 F2 (0.45) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL14321219 0.77 ALDH1A1 (0.60) CRHBPCRHR2KMT2AMEN1KDM4E
SCHEMBL14321689 0.77 ALDH1A1 (0.44) CRHBPCRHR2KMT2AMEN1KDM4E
SCHEMBL5475832 0.76 S1PR3 (0.45) CRHBPCRHR2KMT2AMEN1APOBEC3A
SCHEMBL1197438 0.76 CRHBP (0.44) CRHBPCRHR2KMT2AMEN1APOBEC3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118715231-A Complement factor inhibitors and uses thereof 安尼艾克松股份有限公司 2024-09-27 CN disclosed