Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312050 | 0.86 | KDM4E (0.44) | MAPTMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL313004 | 0.86 | ATM (0.52) | MAPTMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL311431 | 0.85 | HPGD (0.46) | MAPTMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL312609 | 0.84 | HPGD (0.42) | MAOBCYP1A2CYP2C9CYP2C19TYR | |
| SCHEMBL312477 | 0.84 | BACE1 (0.61) | MAPTMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL311136 | 0.84 | ABL1 (0.40) | MAOBCYP1A2CYP2C9CYP2C19TYR | |
| SCHEMBL313061 | 0.84 | MAOB (0.38) | MAOBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL312748 | 0.82 | TYR (0.44) | MAOBTYRPTPN1PTGS1BACE1 | |
| SCHEMBL311741 | 0.82 | KDM4E (0.40) | MAOBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL311784 | 0.81 | AKR1B1 (0.46) | MAPTMAOBCYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |