Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.50 |
| ▸ | TUBB | P07437 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097387 | 0.91 | KCNQ2 (0.57) | LMNAMAPK1HIF1AKCNQ2KMT2A | |
| SCHEMBL11104041 | 0.90 | LMNA (0.56) | LMNAMAPK1HIF1AKCNQ2KMT2A | |
| SCHEMBL31265132 | 0.88 | TUBB4A (0.61) | LMNAMAPK1HIF1AKMT2AMEN1 | |
| SCHEMBL14097391 | 0.87 | KCNQ2 (0.49) | LMNAMAPK1HIF1AKCNQ2KMT2A | |
| SCHEMBL11096138 | 0.86 | TUBB4A (0.48) | LMNAMAPK1HIF1AKMT2AMEN1 | |
| SCHEMBL14097446 | 0.86 | TUBB4A (0.50) | LMNAMAPK1HIF1AKCNQ2KMT2A | |
| SCHEMBL31265123 | 0.84 | KDM4E (0.51) | LMNAMAPK1HIF1AKMT2AMEN1 | |
| SCHEMBL31265133 | 0.83 | KDM4E (0.53) | LMNAMAPK1HIF1AALDH1A1ALOX15 | |
| SCHEMBL14097390 | 0.82 | SMN1; SMN2 (0.54) | LMNAMAPK1HIF1AKCNQ2KMT2A | |
| SCHEMBL11809362 | 0.81 | LMNA (0.51) | LMNAMAPK1HIF1AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249488-A2 | INHIBITORS OF DYRK1A | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2024-12-05 | — | — | WO | disclosed |