Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329762 | 0.78 | MAPT (0.58) | HTTPRKCQHTR6LMNAMEN1 | |
| SCHEMBL3019638 | 0.78 | PRKCQ (0.38) | HTTPRKCQLMNAL3MBTL1MAPT | |
| SCHEMBL9538744 | 0.75 | TXNRD1 (0.59) | HTTPRKCQHTR6LMNAMEN1 | |
| SCHEMBL1736587 | 0.74 | NPC1 (0.70) | HTTPRKCQLMNAMEN1KMT2A | |
| SCHEMBL15348372 | 0.74 | MAPT (0.50) | HTTPRKCQHTR6LMNAMEN1 | |
| SCHEMBL2562058 | 0.74 | NTRK1 (0.47) | HTTHTR6MEN1KMT2AMAPT | |
| SCHEMBL2562056 | 0.74 | NTRK1 (0.47) | HTTHTR6MEN1KMT2AMAPT | |
| SCHEMBL3136036 | 0.74 | ADRB2 (0.37) | LMNAMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2570152 | 0.74 | ADRB2 (0.37) | LMNAMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL2570151 | 0.74 | ADRB2 (0.37) | LMNAMEN1KMT2AL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |