Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31267772 | 1.00 | NR1H2 (0.41) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL29574186 | 0.82 | PARP1 (0.42) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL24265511 | 0.82 | PARP1 (0.42) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL15205695 | 0.82 | MAP4K4 (0.42) | NR1H2MAP4K4ESR2GPR119PDE4B | |
| SCHEMBL31271932 | 0.81 | GPR119 (0.54) | MAP4K4SMARCA2SMARCA4PBRM1HTT | |
| SCHEMBL904194 | 0.79 | NR1H2 (0.42) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL4288899 | 0.79 | NR1H2 (0.49) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL19381743 | 0.78 | NR1H2 (0.43) | NR1H2MAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL21360344 | 0.78 | ENPP2 (0.45) | NR1H2MAP4K4ESR2GPR119MKNK1 | |
| SCHEMBL1206883 | 0.78 | ALDH1A1 (0.47) | NR1H2ESR2GPR119ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724441-A1 | ISOINDOLINONE AND DIHYDROPYRROLOPRIDINONE COMPOUNDS AND USES THEREOF | Revir Therapeutics, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| WO-2024251212-A1 | ISOINDOLINONE AND DIHYDROPYRROLOPRIDINONE COMPOUNDS AND USES THEREOF | REVIR THERAPEUTICS, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| WO-2024251211-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR MODULATING SPLICING OF MSH3 | REVIR THERAPEUTICS, INC. (US) | 2024-12-12 | — | — | WO | disclosed |