Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1339338 | 0.99 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1339069 | 0.91 | GABRA1 (0.36) | GABRA1GABRG2GABRB3GABRA5KDM4E | |
| SCHEMBL1338559 | 0.88 | CYP1A2 (0.33) | KDM4ENPC1LMNATP53RAB9A | |
| SCHEMBL1339414 | 0.84 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA5KDM4E | |
| SCHEMBL1339125 | 0.82 | KMT2A (0.40) | GABRA1GABRG2GABRB3GABRA5KDM4E | |
| SCHEMBL1338855 | 0.81 | — | — | |
| SCHEMBL1338502 | 0.80 | GABRA1 (0.35) | GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1339086 | 0.78 | L3MBTL1 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4761976 | 0.75 | KDM4E (0.35) | GABRA1GABRG2GABRB3GABRA5KDM4E | |
| SCHEMBL1339328 | 0.73 | KMT2A (0.34) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |